Trimipramine's primary use in medicine is in the treatment of major depressive disorder, especially where sedation is helpful due to its prominent sedative effects. The drug is also an effective anxiolytic, … Afficher plus

Contraindications include:
• Recent myocardial infarction
• Any degree of heart block or other cardiac arrhythmias Afficher plus

Compared to other TCAs, trimipramine is relatively safe in overdose, although it is more dangerous than the selective serotonin reuptake … Afficher plus

Pharmacodynamics
The mechanism of action of trimipramine in terms of its antidepressant effects differs from that of … Afficher plus

The side effects of trimipramine have been said to be similar to those of other tertiary amine TCAs, with a preponderance of anticholinergic Afficher plus

Trimipramine should not be given with sympathomimetic agents such as epinephrine (adrenaline), ephedrine, isoprenaline Afficher plus

Trimipramine is a tricyclic compound, specifically a dibenzazepine, and possesses three rings fused together with a Afficher plus